‘Excel Saga’

Quack Experimental Anime Excel Saga presents the weird adventures of Excel, a hyper and super-enthusiastic girl who is employed by the super-secret organization “ACROSS” the aim of which is to take over the world. She will do anything for her beloved Illpalazzo, the leader of ACROSS. She is joined in her antics by the always-dying Hyatt, the next-door neighbor boys, Nabeshin the director, Menchi the puppy, Pedro the immigrant worker and the Grand Will of the Macrocosm!

Descriptions taken from AniDB.net